| Father | James Nehemiah Howard Sr. (1735 - 1798) |
| Mother | Edith "Ede" Smith (1740 - 1829) |
| Sibling | Archer Archibald Howard (1756 - ) |
| Sibling | Sarah Howard (1758 - 1843) |
| Sibling | John Harrison Howard (1761 - 1822) |
| Sibling | Hannah Howard (1763 - ) |
| Sibling | Archibald Howard (1768 - ) |
| Sibling | Joseph H. Howard (1772 - 1849) |
| Sibling | Nehemiah Mealing Howard (1773 - 1856) |
| Sibling | Nancy Ann Howard (1773 - 1852) |
| Sibling | Mary Elizabeth Howard (1774 - 1807) |
| Sibling | James Howard Howard (1776 - 1856) |
| Sibling | Harmon Howard (1778 - 1793) |
| Sibling | Isaiah Howard (1783 - ) |
| Sibling | Rev. Mark Howard (1784 - 1852) |