| Father | Godfrey S. Isaacs (1775 - 1858) |
| Mother | Elizabeth "Betsey" Howard (1790 - 1870) |
| Sibling | John B. Isaacs (1811 - 1894) |
| Sibling | William Isaacs (1812 - 1860) |
| Sibling | Rachel Isaacs (1815 - ) |
| Sibling | Evaline Isaacs (1817 - 1900) |
| Sibling | Caroline Isaacs (1818 - ) |
| Sibling | Nancy Isaacs (1819 - ) |
| Sibling | Samuel Isaacs (1820 - 1899) |
| Sibling | Elizabeth Isaacs (1821 - ) |
| Sibling | Godfrey Isaacs (1825 - ) |
| Sibling | Elisha Isaacs (1827 - 1904) |
| Sibling | Rebecca Isaacs (1830 - ) |
| Sibling | Fielding Isaacs (1831 - 1858) |
| Sibling | Anna Jane Isaacs (1832 - ) |
| Sibling | Henry Stubblefield Isaacs (1835 - 1912) |