| Spouse | Sir Randall BRERETON (1485 - 1530) |
| Child | Lady Elizabeth SOMERSET BRERETON (1481 - 1545) |
| Child | Joan BRERETON (1473 - 1545) |
| Child | Sir Randal BRERETON (1493 - 1573) |
| Child | Sir William BRERETON (1498 - 1536) |
| Child | Sir Urian BRERETON (1501 - 1577) |
| Child | Lady Mary Anne BRERETON (1503 - 1588) |
| Child | Sir Richard BRERETON (1504 - 1558) |
| Child | Lady Elizabeth BRERETON (1505 - 1545) |
| Child | Sir Roger BRERETON (1506 - 1567) |
| Child | Chaplain Peter BRERETON (1507 - 1560) |
| Child | Rector Thomas BRERETON (1511 - 1511) |
| Child | Lady Eleanor BRERETON EGERTON (1515 - 1567) |
| Child | Robert BRERETON (1520 - 1590) |
| Child | Margaret BRERETON (1520 - 1590) |