| Father | Sir Randall BRERETON (1485 - 1530) |
| Mother | Lady Eleanor DUTTON (1470 - 1532) |
| Sibling | Lady Elizabeth SOMERSET BRERETON (1481 - 1545) |
| Sibling | Joan BRERETON (1473 - 1545) |
| Sibling | Sir Randal BRERETON (1493 - 1573) |
| Sibling | Sir William BRERETON (1498 - 1536) |
| Sibling | Sir Urian BRERETON (1501 - 1577) |
| Sibling | Lady Mary Anne BRERETON (1503 - 1588) |
| Sibling | Sir Richard BRERETON (1504 - 1558) |
| Sibling | Lady Elizabeth BRERETON (1505 - 1545) |
| Sibling | Sir Roger BRERETON (1506 - 1567) |
| Sibling | Rector Thomas BRERETON (1511 - 1511) |
| Sibling | Lady Eleanor BRERETON EGERTON (1515 - 1567) |
| Sibling | Robert BRERETON (1520 - 1590) |
| Sibling | Margaret BRERETON (1520 - 1590) |