| Father | Sir Thomas De Grenville (1449 - 1513) |
| Mother | Isabella Gilbert (1451 - 1494) |
| Sibling | Roger Grenville (1477 - 1524) |
| Sibling | Agnes Grenville (1485 - 1537) |
| Sibling | John Grenville (1492 - 1513) |
| Sibling | Richard Grenville (1480 - 1541) |
| Sibling | Catharine Grenville (1480 - 1546) |
| Sibling | Richard Grenville (1473 - 1545) |
| Sibling | Anne Grenville (1485 - ) |
| Sibling | Philippa Grenville (1483 - 1524) |
| Sibling | Richard Grenville (1475 - ) |
| Sibling | Jane Grenville (1494 - 1568) |
| Sibling | Mary Grenville (1483 - 1537) |
| Sibling | Richard Granville (1479 - ) |
| Sibling | Lady Honor Grenville (1476 - 1563) |