| Spouse | Isabella Gilbert (1451 - 1494) |
| Child | Roger Grenville (1477 - 1524) |
| Child | Agnes Grenville (1485 - 1537) |
| Child | Jane Grenville (1474 - 1551) |
| Child | John Grenville (1492 - 1513) |
| Child | Richard Grenville (1480 - 1541) |
| Child | Catharine Grenville (1480 - 1546) |
| Child | Richard Grenville (1473 - 1545) |
| Child | Anne Grenville (1485 - ) |
| Child | Philippa Grenville (1483 - 1524) |
| Child | Richard Grenville (1475 - ) |
| Child | Jane Grenville (1494 - 1568) |
| Child | Mary Grenville (1483 - 1537) |
| Child | Richard Granville (1479 - ) |
| Child | Lady Honor Grenville (1476 - 1563) |