| Father | William Christopher LOCKE (1730 - 1785) |
| Mother | Agnes Thweat HARDAWAY (1733 - 1799) |
| Sibling | Jacob LOCKE (1749 - 1785) |
| Sibling | George LOCKE (1750 - 1823) |
| Sibling | John LOCKE (1751 - 1834) |
| Sibling | Samuel William LOCKE ( - ) |
| Sibling | Jesse LOCKE (1754 - 1815) |
| Sibling | Elizabeth LOCKE (1757 - 1791) |
| Sibling | Elisha LOCKE (1760 - 1849) |
| Sibling | Richard LOCKE (1762 - 1845) |
| Sibling | Stephen LOCKE (1765 - ) |
| Sibling | Thomas LOCKE (1769 - ) |
| Sibling | Abraham Samuel LOCKE (1772 - 1844) |
| Sibling | Mary LOCKE (1772 - 1801) |
| Sibling | Job LOCKE (1776 - 1859) |
| Sibling | William LOCKE (1779 - 1854) |
| Sibling | Willis LOCKE (1780 - 1865) |