| Spouse | William Christopher LOCKE (1730 - 1785) |
| Child | Jacob LOCKE (1749 - 1785) |
| Child | George LOCKE (1750 - 1823) |
| Child | John LOCKE (1751 - 1834) |
| Child | Samuel William LOCKE ( - ) |
| Child | Jesse LOCKE (1754 - 1815) |
| Child | Elizabeth LOCKE (1757 - 1791) |
| Child | Elisha LOCKE (1760 - 1849) |
| Child | Richard LOCKE (1762 - 1845) |
| Child | Stephen LOCKE (1765 - ) |
| Child | Billy Francis LOCKE (1767 - 1858) |
| Child | Thomas LOCKE (1769 - ) |
| Child | Abraham Samuel LOCKE (1772 - 1844) |
| Child | Mary LOCKE (1772 - 1801) |
| Child | Job LOCKE (1776 - 1859) |
| Child | William LOCKE (1779 - 1854) |
| Child | Willis LOCKE (1780 - 1865) |