| Father | John S. HEFFNER Sr. (1797 - 1881) |
| Mother | Rachel ENYEART (1800 - 1871) |
| Sibling | Benjamin Franklin "Ben" HEFFNER (1820 - 1894) |
| Sibling | Nancy HEFFNER (1822 - 1851) |
| Sibling | Adam HEFFNER (1824 - 1901) |
| Sibling | Elizabeth HEFFNER (1826 - 1851) |
| Sibling | Rebecca HEFFNER (1828 - 1905) |
| Sibling | Andrew HEFFNER (1829 - 1872) |
| Sibling | John HEFFNER Jr. (1831 - 1895) |
| Sibling | Catherine HEFFNER (1833 - 1864) |
| Sibling | Peter HEFFNER (1833 - 1915) |
| Sibling | Mary Anne/Ann HEFFNER (1838 - 1919) |
| Sibling | Margaret HEFFNER (1840 - 1910) |
| Sibling | William HEFFNER (1843 - 1843) |
| Sibling | Orlady HEFFNER (1844 - 1865) |
| Sibling | William N. HEFFNER (1847 - ) |