| Father | John Christian CLAY Sr. (1794 - 1844) |
| Mother | Maria Barbara HOY (1800 - 1867) |
| Sibling | George CLAY (1815 - 1834) |
| Sibling | William CLAY (1819 - 1894) |
| Sibling | Elizabeth CLAY (1821 - 1912) |
| Sibling | Peggy CLAY (1822 - 1824) |
| Sibling | John CLAY Jr. (1824 - 1908) |
| Sibling | Alfred Sidney CLAY (1826 - 1905) |
| Sibling | Mary Barbara CLAY (1828 - ) |
| Sibling | Jeremiah CLAY (1830 - 1890) |
| Sibling | Catherine CLAY (1831 - 1912) |
| Sibling | Hiram CLAY (1833 - 1909) |
| Sibling | Daniel Reuben CLAY (1835 - 1921) |
| Sibling | Henry Adam CLAY (1837 - 1837) |
| Sibling | Margaret Christina CLAY (1839 - 1911) |
| Sibling | Rebecca CLAY (1840 - 1840) |
| Sibling | Christina Magdalena CLAY (1842 - 1920) |
| Sibling | Levi CLAY (1843 - 1917) |