| Spouse | James Houston (1755 - 1837) |
| Child | Prudence Houston (1795 - 1871) |
| Child | John Y Houston (1776 - 1849) |
| Child | Nancy Houston (1780 - ) |
| Child | James Ross Houston (1782 - ) |
| Child | Mary Houston (1787 - 1855) |
| Child | John Houston (1788 - 1839) |
| Child | James Houston (1794 - ) |
| Child | David Ross Houston (1796 - ) |
| Child | Margaret "Peggy" Houston (1798 - 1863) |
| Child | David Ross Houston (1805 - 1865) |
| Child | Young Gresham Houston (1805 - 1870) |
| Child | Lucinda Houston (1808 - 1864) |
| Child | Eunice Nancy Houston (1809 - ) |
| Child | Leonidas Young Houston (1814 - ) |