| Spouse | Hester Dyer (1731 - 1816) |
| Child | John Patton (1747 - 1804) |
| Child | Matthew Patton Jr (1750 - 1834) |
| Child | Roger Dyer Patton (1751 - 1811) |
| Child | William Patton (1752 - 1810) |
| Child | Samuel Patton (1753 - 1793) |
| Child | John William Patton (1754 - 1846) |
| Child | Solomon Patton (1757 - 1811) |
| Child | Benjamin Patton (1760 - 1808) |
| Child | Sarah Patton (1762 - 1795) |
| Child | Mary Ann Patton (1763 - 1813) |
| Child | James Patton (1765 - 1823) |
| Child | Roger Dyer Patton (1766 - 1813) |
| Child | Esther Dyer Patton (1769 - 1856) |
| Child | David Patton (1770 - ) |
| Child | Eliza Patton (1774 - ) |