| Father | John Calvin McGuire (1812 - 1885) |
| Mother | Rachael Tabitha Moore (1814 - 1887) |
| Sibling | William Jasper McGuire (1836 - 1926) |
| Sibling | Samuel Tillman McGuire (1837 - 1890) |
| Sibling | John Peter McGuire (1838 - 1931) |
| Sibling | Samuel Uriah McGuire (1840 - 1902) |
| Sibling | Mary Jane McGuire (1840 - 1919) |
| Sibling | Nancy K McGuire (1845 - ) |
| Sibling | James Andrew McGuire Sr. (1845 - 1923) |
| Sibling | Lucinda McGuire (1850 - ) |
| Sibling | Nathaniel Clay McGuire (1852 - 1931) |
| Sibling | George McGuire (1854 - ) |
| Sibling | Joseph Joel Newton McGuire (1856 - 1910) |