| Spouse | Henry Burwell Flowers Sr (1721 - 1795) |
| Child | Thomas Flowers (1740 - ) |
| Child | Jacob Flowers (1742 - ) |
| Child | Archibald "Archie" Flowers (1744 - 1806) |
| Child | Elizabeth " Betsy" Lightfoot Flowers (1745 - ) |
| Child | Nancy Flowers (1747 - 1820) |
| Child | Henry Burwell Flowers Jr. (1748 - 1806) |
| Child | John Flowers (1750 - 1807) |
| Child | James Flowers (1752 - ) |
| Child | Bennett Flowers (1756 - 1830) |
| Child | Mary " Mollie" Flowers (1758 - 1820) |
| Child | William Flowers (1759 - 1829) |
| Child | Mary Martha Elizabeth Flowers (1765 - 1860) |
| Child | Olivia Flowers (1765 - 1820) |
| Child | Sarah Flowers (1772 - ) |