| Spouse | Anna Mae Hellums (1813 - 1870) |
| Child | Lucinda Jeffrey (1829 - 1873) |
| Child | John Rufus Jeffrey (1831 - 1863) |
| Child | Jeremiah Franklin Jeffrey (1833 - 1863) |
| Child | Matthew Bishop Jeffrey (1835 - 1883) |
| Child | William Jeffrey (1838 - ) |
| Child | Jesse Thomas Jeffrey (1840 - 1906) |
| Child | James Pruit Jeffrey (1843 - 1927) |
| Child | Mary Ann Jeffrey (1845 - ) |
| Child | Abigail Jeffrey (1848 - 1859) |
| Child | Egbert Meders Jeffrey (1849 - 1930) |
| Child | Sarah Margaret Jeffrey (1851 - 1916) |
| Child | Aaron Burleson Jeffrey (1854 - 1915) |
| Child | Julia Ann Jeffrey (1857 - 1911) |