| Father | Benjamin T. "Ben" Wheeler I., Sr (1727 - 1807) |
| Mother | Caziah "Kezia" Murray (1729 - 1806) |
| Sibling | Rachel Murray Wheeler (1745 - 1865) |
| Sibling | Nicholas Wheeler Sr (1750 - 1839) |
| Sibling | Elizabeth Wheeler (1752 - 1822) |
| Sibling | Dr William Samuel Wheeler (1755 - 1825) |
| Sibling | Pvt Benjamin Thomas Wheeler II (1758 - 1848) |
| Sibling | Nancy Ann Wheeler (1759 - 1846) |
| Sibling | Keziah Wheeler (1760 - 1834) |
| Sibling | James Wheeler (1762 - 1834) |
| Sibling | Richard Wheeler (1763 - 1808) |
| Sibling | Isabella Wheeler (1765 - 1852) |
| Sibling | Mordecai William Wheeler (1766 - 1885) |