| Spouse | Dorothea Spottswood (1733 - 1770) |
| Child | Ann Dandridge (1687 - 1776) |
| Child | Nathaniel West Dandridge ( - ) |
| Child | Martha Dandridge (1748 - 1791) |
| Child | William Alexander Dandridge (1750 - 1801) |
| Child | Alexander Spottswood Dandridge (1753 - ) |
| Child | John Dandridge (1756 - 1804) |
| Child | Dorthea Spottswood Dandridge (1757 - 1831) |
| Child | Robert Ambler Dandridge (1760 - ) |
| Child | Elizabeth Dandridge (1764 - 1833) |
| Child | Anna Katharina Dandridge (1767 - ) |
| Child | Mary Claiborne Dandridge (1772 - ) |
| Child | Unity Spottswood Dandridge (1799 - 1823) |