| Spouse | Isabella Trotta (1695 - 1765) |
| Child | Antonia Anna Vittoria Lopardi (1721 - 1771) |
| Child | Venantio Nicola Lopardi (1723 - ) |
| Child | Cono Lopardi (1724 - 1797) |
| Child | Rosa Maria Agnesa Lopardi (1725 - 1764) |
| Child | Antonia Lopardi (1726 - 1781) |
| Child | Antonia Faustina Lopardi (1728 - 1728) |
| Child | Margarita Faustina Lopardi (1729 - 1729) |
| Child | Lucia Anna Lopardi (1730 - 1739) |
| Child | Geronima Faustina Lopardi (1732 - 1733) |
| Child | Giovanna Faustina Lopardi (1734 - 1737) |
| Child | Arcangela Antonia Lopardi (1736 - ) |
| Child | Faustina Lopardi (1738 - 1739) |