| Father | Sir William DE BRERETON XI Lord of Brereton (1414 - 1456) |
| Mother | Lady Philippa DE HULSE of Brereton (1416 - 1463) |
| Sibling | Margaret BRERETON (1455 - 1539) |
| Sibling | Eleanor BRERETON (1450 - 1497) |
| Sibling | William BRERETON Esquire, Knight (1438 - ) |
| Sibling | Hugh BRERETON of Wimbersley (1444 - 1527) |
| Sibling | Matthew BRERETON (1446 - ) |
| Sibling | Robert BRERETON (1440 - 1463) |
| Sibling | Sir Andrew BRERETON (1448 - 1527) |
| Sibling | Sir Thomas BREYTON (1436 - 1500) |
| Sibling | Henry BRERETON (1442 - ) |
| Sibling | Matilda BRERETON (1447 - ) |
| Sibling | Joan BRERETON (1454 - 1517) |
| Sibling | John BRERETON (1442 - 1486) |