| Spouse | Sarah Ann Lowe (1794 - 1881) |
| Child | Augustus James (1817 - 1850) |
| Child | Alfred James (1821 - 1863) |
| Child | Martha James (1822 - ) |
| Child | Dennis James (1825 - ) |
| Child | Hollis James Jr (1826 - ) |
| Child | William James (1829 - ) |
| Child | Mary James (1830 - ) |
| Child | Sarah Jane James (1830 - ) |
| Child | Thomas Jefferson James (1832 - ) |
| Child | Mary James (1834 - ) |
| Child | Theodore James (1836 - ) |
| Child | John W James (1837 - ) |
| Child | Susannah James (1838 - ) |
| Child | Lemuel James (1840 - 1916) |
| Child | Hannah James (1841 - ) |
| Child | Perry James (1843 - ) |
| Child | Daniel James (1844 - ) |
