| Father | Robert H. Higginbotham (1777 - 1831) |
| Mother | Emily "Milly" Strickland (1784 - 1840) |
| Sibling | Judge Solomon Higginbotham (1800 - 1843) |
| Sibling | Henry Higginbotham (1803 - ) |
| Sibling | Letitia Higginbotham (1804 - 1860) |
| Sibling | Lurena Higginbotham (1809 - 1880) |
| Sibling | Sophia Higginbotham (1811 - 1841) |
| Sibling | Louisa Higginbotham (1812 - 1848) |
| Sibling | Madison Green Higginbotham (1813 - ) |
| Sibling | Mary Higginbotham (1817 - ) |
| Sibling | Thomas Taliaferro Higginbotham (1823 - 1859) |
| Sibling | Dr. Robert Jasper Higginbotham (1824 - 1849) |