| Father | John Hancock (1688 - 1775) |
| Mother | Anna Webb (1696 - 1771) |
| Sibling | Thomas Hancock I (1727 - 1804) |
| Sibling | Martha Hancock (1742 - 1742) |
| Sibling | Abigail Hancock (1734 - 1815) |
| Sibling | Mary Hancock (1716 - 1766) |
| Sibling | Experience Hancock (1730 - 1780) |
| Sibling | Daniel Hancock (1732 - 1784) |
| Sibling | John Hancock (1717 - 1770) |
| Sibling | Silas Jabez HANCOCK (1728 - 1815) |
| Sibling | Jonathan Hancock (1724 - 1778) |
| Sibling | William Hancock (1729 - 1824) |
| Sibling | Mercy Hancock (1735 - 1800) |
| Sibling | Anna Hancock (1719 - 1740) |
| Sibling | Mabel Hancock (1726 - 1806) |
| Sibling | Abel Hancock (1721 - 1807) |