| Spouse | Mary Burnwell (1606 - ) |
| Child | Lord Horatio Walpole (1678 - 1757) |
| Child | Lady Nancy Walpole (1696 - ) |
| Child | Mary Walpole (1673 - 1730) |
| Child | Dorothy Walpole (1686 - 1726) |
| Child | Dorothy Walpole (1678 - ) |
| Child | Christepher Walpole (1679 - 1681) |
| Child | Nancy Walpole (1681 - 1737) |
| Child | John Walpole (1677 - ) |
| Child | Mr. Walpole (1672 - ) |
| Child | Burwell Walpole (1675 - ) |
| Child | Mardaunt Walpole (1688 - 1688) |
| Child | (Sir) Robert Walpole (1671 - 1745) |
| Child | Elizabeth Walpole (1680 - 1681) |
| Child | Susan Walpole (1687 - 1763) |
| Child | Susan Walpole (1672 - ) |
| Child | Charles Walpole (1691 - ) |
| Child | William Walpole (1693 - 1694) |
| Child | Anne Walpole (1685 - 1685) |
| Child | Edward Walpole (1670 - 1697) |
| Child | Galfedus Walpole (1648 - 1726) |