| Spouse | Thomas Sampson Lanier (1682 - 1743) |
| Child | Elizabeth Lanier (1720 - 1755) |
| Child | Nathaniel Lanier (1717 - ) |
| Child | Elizabeth Ann Lee (1700 - ) |
| Child | Mary Lanier (1763 - ) |
| Child | Sampson Lanier Jr (1685 - 1757) |
| Child | James Henry Lanier (1724 - 1786) |
| Child | Isom Isham Lanier (1762 - ) |
| Child | Cynthia Lanier (1760 - ) |
| Child | William Lanier (1720 - ) |
| Child | Thomas Bird Lanier (1703 - 1757) |
| Child | Elizabeth Lainer (1709 - 1774) |
| Child | Nathaniel Lanier (1749 - 1814) |
| Child | Henry Lanier (1757 - ) |
| Child | Lemuel Lanier (1728 - 1793) |
| Child | Lucretia Lanier (1764 - ) |
| Child | Nicholas Shepherd Lanier (1717 - ) |
| Child | John Lanier (1765 - ) |
| Child | Lucy Lanier (1675 - ) |
| Child | Laniers ( - ) |
| Child | Abbie Lanier (1761 - ) |
| Child | Clement Lanier (1737 - ) |
| Child | Richard Lainer (1715 - ) |
| Child | Lydia Lanier (1758 - ) |
| Child | Arthur Lanier (1706 - 1743) |
| Child | Robert Lanier (1678 - 1756) |