| Father | Sir Edward LITTLETON (1550 - 1622) |
| Sibling | Edward LITTLETON (1550 - 1622) |
| Sibling | Jane (or Joan) LITTLETON (OSBALDESTON) (1570 - ) |
| Sibling | Anne LITTLETON (KETTLEBY) (1583 - ) |
| Sibling | Sir Edward LITTLETON, LORD LITTLETON (1588 - 1645) |
| Sibling | Agnes LITTLETON (1588 - ) |
| Sibling | William LITTLETON (1591 - 1645) |
| Sibling | James LITTLETON D.C.L., CHANCELLOR OF WORCESTE (1592 - 1645) |
| Sibling | Martha LITTLETON (1593 - 1603) |
| Sibling | John LITTLETON, MASTER OF THE TEMPLE (1596 - 1643) |
| Sibling | Sir Timothy LITTLETON (1598 - 1679) |
| Sibling | Samuel LITTLETON (1600 - ) |
| Sibling | Martha LITTLETON (1603 - 1603) |
| Sibling | James LITTLETON (1604 - ) |
| Sibling | Jane LITTLETON (1604 - 1691) |
| Sibling | Joanna LITTLETON (1608 - ) |
| Sibling | Mary LITTLETON (1610 - ) |