| Father | William DE CANTILUPE (1180 - 1251) |
| Mother | Millicent GOURNAY (1189 - 1260) |
| Sibling | Sir William DE CANTILUPE III (1217 - 1254) |
| Sibling | Agnes DE CANTILUPE (1216 - 1279) |
| Sibling | Nicole DE CANTILUPE (1217 - 1257) |
| Sibling | Thomas DE CANTILUPE Bishop of Hereford (1218 - 1282) |
| Sibling | John of Smithfield CANTALOU (1219 - ) |
| Sibling | Nicholas DE CANTILUPE (1220 - ) |
| Sibling | Sibilla DE CANTILUPE (1222 - 1278) |
| Sibling | John CANTILUPE (1224 - ) |
| Sibling | Hugh DE CANTILUPE (1226 - 1279) |
| Sibling | Hugh CANTILUPE (1226 - ) |
| Sibling | Nicholas DE CANTELUPE OR DE CANTELOU (1230 - 1266) |