| Father | Sir Hugh the Younger LE DESPENSER, III (2009 - 1326) |
| Mother | Eleanor DE CLARE (1292 - 1337) |
| Sibling | Edward DESPENSER I (1310 - 1342) |
| Sibling | Baron Hugh, 1st Baron le Despenser LE DESPENSER (1308 - 1349) |
| Sibling | Sir Gilbert LE DESPENSER (DESPENSER) (1309 - 1381) |
| Sibling | Gilbert LE DESPENSER (1309 - 1382) |
| Sibling | (Sir) John LE DESPENSER (1311 - 1366) |
| Sibling | Isabel LE DESPENSER (1314 - 1371) |
| Sibling | Sir Edward LE DESPENSER (DESPENSER) (1315 - 1342) |
| Sibling | Sister Joan LE DESPENSER (1316 - 1384) |
| Sibling | John le DESPENSER (1317 - 1366) |
| Sibling | Margaret DESPENCER (1318 - 1337) |
| Sibling | Eleanor LE DESPENSER (1319 - 1351) |
| Sibling | Margaret LE DESPENSER (1323 - 1337) |
| Sibling | Elizabeth LE DESPENSER (1327 - 1389) |