| Father | Sir Randle DE BRERETON Knight (1414 - 1478) |
| Mother | Lady Katharine BULKELEY (1425 - 1468) |
| Sibling | Sir Randall BRERETON III (1457 - 1536) |
| Sibling | William BRERETON OF BORRAS (1427 - ) |
| Sibling | Cicely BRERETON (1437 - ) |
| Sibling | Annes BRERETON (1440 - ) |
| Sibling | Alice BRERETON (1445 - ) |
| Sibling | Anna BRERETON (1449 - ) |
| Sibling | Thomas BRERETON (1454 - 1511) |
| Sibling | Bartholomew BRERETON (1459 - 1525) |
| Sibling | Eleanor BRERETON (1460 - 1567) |
| Sibling | Matilda Noel (1462 - ) |
| Sibling | Elizabeth BRERETON (1445 - 1545) |
| Sibling | John BRERETON (1445 - ) |
| Sibling | Nicholas BRERETON (1445 - ) |
| Sibling | Owen BRERETON (1445 - ) |
| Sibling | Isabel BRERETON ( - ) |