| Father | Robert HOLME (1439 - 1503) |
| Mother | Margaret Marion DE CONSTABLE (1460 - 1510) |
| Sibling | John William HOLME (1478 - 1541) |
| Sibling | Katherine HOLMES (1477 - 1528) |
| Sibling | Robert DEL HOLME LORD OF TANMURE (1480 - 1524) |
| Sibling | William HOLME Of Paull Holme (1482 - 1524) |
| Sibling | John HOLMES Esq. Lord of Paull-Holme (1485 - 1542) |
| Sibling | Ralph HOLMES (1488 - 1504) |
| Sibling | Stephen HOLMES (1494 - 1519) |
| Sibling | Margery HOLMES (1496 - ) |
| Sibling | Robert HOLME (1498 - 1543) |
| Sibling | Isabell HOLMES (1500 - ) |
| Sibling | Hugh de HOLME, LORD OF TANMURE (1502 - ) |