| Spouse | William Overton Rutherford Sr (1727 - 1801) |
| Child | Randolph Rutherford (1758 - 1841) |
| Child | Samuel R Rutherford (1768 - 1839) |
| Child | Archibald Hamilton Rutherford (1768 - 1825) |
| Child | Archelaus Rutherford (1765 - ) |
| Child | Ursula Rutherford (1770 - 1828) |
| Child | Absalom Rutherford (1763 - 1841) |
| Child | Benjamin Rutherford (1770 - 1860) |
| Child | William Rutherford (1763 - 1813) |
| Child | Finney Phineas Rutherford (1773 - 1861) |
| Child | Thomas Rutherford (1760 - 1845) |
| Child | John Rutherford (1760 - 1839) |
| Child | Lossane Rutherford (1756 - ) |
| Child | David Rutherford ( - ) |
| Child | Julius Rutherford (1756 - 1831) |
| Child | Archibald Rutherford (1754 - 1838) |
| Child | Sarah Davenport (1751 - 1801) |
| Child | John Rutherford ( - ) |
| Child | Mary Rutherford (1750 - ) |
| Child | Joseph Rutherford ( - ) |
| Child | Susannah Rutherford (1750 - 1839) |
| Child | William Rutherford Jr (1748 - ) |