| Spouse | Arthur Francis Hopkins Jr. (1699 - 1767) |
| Child | Mary Hopkins (1735 - 1811) |
| Child | Anna Hopkins (1732 - 1781) |
| Child | Amelia Hopkins (1742 - 1823) |
| Child | Anne Paine Hopkins (1732 - 1807) |
| Child | Arthur Hopkins (1727 - 1776) |
| Child | Samuel Hopkins M. D. (1725 - 1796) |
| Child | Elizabeth Hopkins (1728 - 1807) |
| Child | Jane Hopkins (1738 - 1802) |
| Child | Frances Hopkins (1738 - 1790) |
| Child | Isabella Hopkins (1748 - 1800) |
| Child | Lucy Hopkins (1741 - 1817) |
| Child | John M. Hopkins (1726 - 1805) |
| Child | William Hopkins (1740 - 1820) |
| Child | James Hopkins (1730 - 1803) |