| Father | Jesse Irvine (1792 - 1876) |
| Mother | Clementina Cabell (1794 - 1841) |
| Sibling | William Cabell Irvine (1816 - 1851) |
| Sibling | Martha Irvine (1817 - 1819) |
| Sibling | Ann Cabell Irvine (1820 - 1897) |
| Sibling | Edward Cabell Irvine (1821 - 1898) |
| Sibling | Elvira Bruce Irvine (1822 - 1823) |
| Sibling | Sarah Cabell Irvine (1825 - 1899) |
| Sibling | Patrick Cabell Irvine M. D. (1827 - 1854) |
| Sibling | Jessie Irvine (1832 - ) |
| Sibling | Mary Eliza Irvine (1832 - 1919) |
| Sibling | Juliet Cabell Irvine (1835 - 1924) |
| Sibling | Margaret Frances Irvine (1837 - 1883) |