| Father | William Jasper Spence (1816 - 1859) |
| Mother | Christiana Aubert (1822 - 1890) |
| Sibling | Matilda Caroline Spence (1846 - 1926) |
| Sibling | Thomas Spence (1854 - 1900) |
| Sibling | Charlotte Spence (1850 - 1912) |
| Sibling | William Jasper Spence Jr. (1840 - 1859) |
| Sibling | Judge William Albert Spence (1855 - 1932) |
| Sibling | Samuel Spence (1845 - 1862) |
| Sibling | George Spence (1852 - 1853) |
| Sibling | Georgia Spence (1853 - 1920) |
| Sibling | Henrietta Cornelia Spence (1849 - 1927) |
| Sibling | James Spence (1846 - 1872) |
| Sibling | Sarah Spence (1842 - 1910) |
| Sibling | Sarah Deborah Spence (1842 - 1910) |