| Spouse | John Odell Northrop (1828 - 1909) |
| Child | Helen Selina Northrop (1856 - ) |
| Child | Thomas Barnes Northrop (1857 - 1859) |
| Child | Harriett Bicknell Northrop (1860 - 1935) |
| Child | Anne A Northrop (1869 - 1954) |
| Child | Mary Wheeler Northrop (1879 - ) |
| Child | John Blair Northrop (1852 - 1872) |
| Child | Horace Barber Northrop (1854 - ) |
| Child | William Stuart Northrop (1863 - 1941) |
| Child | Louis Allan Northrop (1865 - ) |
| Child | Hiram Barnes Northrop (1860 - 1862) |
| Child | Charlotte G. Northrop (1866 - 1943) |
| Child | Edward Worcester Northrop (1871 - 1957) |
| Child | Evelyn Hazleton Northrop (1874 - 1950) |
| Child | Eugene Goodrich Northrup (1878 - 1946) |