| Father | William Sydenham (1593 - 1661) |
| Mother | Mary Jeffery (1593 - 1644) |
| Sibling | Richard Sydenham (1632 - 1657) |
| Sibling | William Sydenham of Wynford Eagle (1615 - 1661) |
| Sibling | Dr Thomas Sydenham (1624 - 1689) |
| Sibling | John Sydenham (1627 - 1651) |
| Sibling | (Maj) Francis Sydenham (1617 - 1645) |
| Sibling | Martha Sydenham ( - 1672) |
| Sibling | Mary Sydenham (1614 - ) |
| Sibling | Robert Sydenham (1622 - 1623) |
| Sibling | Nathaniel Sydenham (1630 - 1638) |
| Sibling | Elizabeth Sydenham (1619 - 1681) |
| Sibling | George Sydenham (1629 - 1629) |
| Sibling | John Sydenham (1621 - 1621) |