| Father | Joseph Duke (1726 - 1779) |
| Mother | Mary Major Bartholomew (1726 - 1789) |
| Sibling | Major Duke (1747 - 1838) |
| Sibling | Sherrod Duke (1746 - 1781) |
| Sibling | Mary Ann "Polly" Duke (1746 - 1783) |
| Sibling | Alice Duke (1748 - ) |
| Sibling | Buckner Andrew Duke (1751 - 1816) |
| Sibling | John R Duke Sr (1752 - 1824) |
| Sibling | Ransom Duke (1754 - 1818) |
| Sibling | William Duke (1756 - 1800) |
| Sibling | Delilah Duke (1758 - 1819) |
| Sibling | Isham L. Duke (1758 - 1826) |
| Sibling | Buckner Duke (1760 - 1816) |
| Sibling | Martha Duke (1764 - 1820) |
| Sibling | Hardiman Hardaway "Hardy" Duke (1765 - 1839) |