| Spouse | Elizabeth Steward (1565 - 1654) |
| Child | Bartholomew Cromwell (1588 - 1660) |
| Child | Ann Cromwell (1589 - 1646) |
| Child | Elizabeth Cromwell (1591 - 1672) |
| Child | Joan Cromwell (1592 - 1600) |
| Child | Huntingdon Cromwell (1593 - 1672) |
| Child | Robina Cromwell (1594 - 1660) |
| Child | Katheren Henrietta Cromwell (1596 - ) |
| Child | Henrietta Morgan Cromwell (1597 - 1660) |
| Child | Catherine Cromwell (1597 - 1635) |
| Child | Oliver Cromwell, 1st Lord Protector of England (1599 - 1658) |
| Child | Margaret Cromwell (1600 - 1650) |
| Child | Jane Cromwell (1605 - 1656) |
| Child | Robert Cromwell ( - 1609) |