| Father | James Presnell I (1714 - 1792) |
| Mother | Mary Ann Daniel (1716 - 1800) |
| Sibling | Elias Presnell (1734 - ) |
| Sibling | Jacob Presnell (1734 - ) |
| Sibling | James Presnell II (1735 - ) |
| Sibling | Abraham Presnell (1735 - ) |
| Sibling | William Presnell (1738 - 1823) |
| Sibling | Sarah Presnell (1739 - ) |
| Sibling | Esau Presnell (1740 - ) |
| Sibling | Mary Ann Daniel (1743 - ) |
| Sibling | Margaret Mary Presnell (1744 - 1831) |
| Sibling | Rachel Presnell (1744 - 1817) |
| Sibling | Gabriel Presnell (1745 - 1779) |
| Sibling | Margaret Presnell (1747 - ) |
| Sibling | Daniel Presnell (1748 - 1830) |
| Sibling | Elizabeth Presnell (1749 - ) |
| Sibling | Jonathan Presnell (1750 - 1840) |
| Sibling | Abraham Presnell (1750 - ) |
| Sibling | Elijah Presnell (1750 - ) |
| Sibling | John Presnell (1751 - ) |
| Sibling | Stephen Presnell (1758 - ) |
| Sibling | Mary Mercy Presnell (1759 - 1796) |
| Sibling | William Presnell (1760 - ) |