| Father | Isaac Otis (1798 - 1858) |
| Mother | Caroline Abigail Curtiss (1808 - 1883) |
| Sibling | George Lorenzo Otis (1829 - 1883) |
| Sibling | Alfred Gideon Otis (1829 - 1912) |
| Sibling | Joseph E. Otis (1831 - 1832) |
| Sibling | Mary Ruth Otis (1833 - 1890) |
| Sibling | Ephraim Allen Otis (1835 - 1913) |
| Sibling | Ruth Cornelia Otis (1837 - 1843) |
| Sibling | Maria Louise Otis (1841 - 1917) |
| Sibling | Isaac Newton Otis (1844 - 1880) |
| Sibling | Stephen Franklin Otis (1847 - 1904) |
| Sibling | Lillian Caroline Otis (1853 - 1895) |
| Sibling | Otis ( - ) |
| Sibling | Otis ( - ) |
| Sibling | Curtiss Gideon Otis (1839 - 1880) |
| Sibling | Charles Eugene Otis (1846 - 1917) |