| Spouse | Margaret Mowbray of Barnbougle (1505 - 1548) |
| Child | Richard Graham (1545 - 1600) |
| Child | Gilbert Graham of Beircrofts and Gartvertane (1510 - 1573) |
| Child | Allan Graham (1521 - 1573) |
| Child | Lady Margaret Mary Graham (1522 - 1556) |
| Child | Lawrence Graham (1522 - 1579) |
| Child | Andrew Graham (1522 - ) |
| Child | John Graham (1523 - 1565) |
| Child | Robert Graham Of Gartmore (1525 - 1573) |
| Child | Walter Graham (1527 - 1565) |
| Child | Christian Graham (1524 - 1597) |
| Child | David or George Grahame (1530 - ) |
| Child | Agnes Grahame (1531 - ) |
| Child | Marion Couttie Mentieth (1532 - 1587) |
| Child | Lady Catherine Kate Graham (1532 - 1630) |
| Child | William Graham (1536 - 1618) |