| Spouse | Jane Cromwell (1605 - 1656) |
| Child | Thomas Desborough I (1625 - 1709) |
| Child | John Desborough (1633 - 1658) |
| Child | Elizabeth Desborough (1635 - 1702) |
| Child | John Disborough ( - 1678) |
| Child | Henry Desborough (1637 - 1699) |
| Child | Richard Desborough (1638 - 1698) |
| Child | Samuel Desborough (1639 - 1699) |
| Child | Jane Desborough (1640 - 1678) |
| Child | Nathaniel Disbrow (1641 - 1678) |
| Child | Nathaniel Desborough (1642 - 1729) |
| Child | Valentine Desborough (1643 - ) |
| Child | Samuel Disbrow (1645 - ) |
| Child | Benjamin (Disbrow) Desborough esq. (1647 - 1708) |