| Spouse | Martha Owen Spencer (1758 - 1833) |
| Child | Mary Holloway (1779 - ) |
| Child | Julia Elizabeth Holloway (1780 - ) |
| Child | Thomas Spencer Holloway (1782 - 1814) |
| Child | John Holloway (1784 - 1843) |
| Child | Martha O Holloway (1790 - 1871) |
| Child | Jonathan T. Holloway (1792 - 1889) |
| Child | Spencer J Holloway (1793 - 1883) |
| Child | Fannie Holloway (1795 - 1850) |
| Child | Samuel J. Holloway (1795 - 1882) |
| Child | Elizabeth Holloway (1798 - 1892) |
| Child | William Holloway (1798 - 1893) |
| Child | George James Holloway (1799 - 1882) |
| Child | Amos Holloway (1808 - 1836) |
| Child | Ezra Holloway (1808 - ) |
| Child | H. H. Holloway (1808 - ) |
| Child | Minter Holloway (1808 - ) |
| Child | Nancy Holloway (1808 - ) |
| Child | Unity Holloway (1808 - ) |
| Child | Joseph Holloway (1813 - 1888) |