| Father | Col Thomas Cole Spencer Jr (1750 - 1806) |
| Mother | Lucy Ann Watkins (1759 - 1847) |
| Sibling | Elizabeth Spencer (1782 - 1854) |
| Sibling | Susan Spencer (1783 - 1856) |
| Sibling | Sarah Spencer (1784 - 1850) |
| Sibling | Gideon Sion Spencer (1786 - 1833) |
| Sibling | Martha Spencer (1788 - ) |
| Sibling | William W. Spencer (1792 - ) |
| Sibling | Thomas J. Spencer (1793 - 1822) |
| Sibling | Mary Spencer (1795 - ) |
| Sibling | Elizabeth Spencer ( - ) |
| Sibling | Lucy Spencer ( - ) |
| Sibling | Patsy Spencer ( - ) |
| Sibling | Polly Spencer ( - ) |
| Sibling | Thomas Edmond Spencer ( - ) |
| Sibling | William Spencer ( - ) |