| Spouse | Mary Ann Daniel (1716 - 1800) |
| Child | Elias Presnell (1734 - ) |
| Child | Jacob Presnell (1734 - ) |
| Child | James Presnell II (1735 - ) |
| Child | Abraham Presnell (1735 - ) |
| Child | William Presnell (1738 - 1823) |
| Child | Sarah Presnell (1739 - ) |
| Child | Esau Presnell (1740 - ) |
| Child | Mary Ann Daniel (1743 - ) |
| Child | Margaret Mary Presnell (1744 - 1831) |
| Child | Rachel Presnell (1744 - 1817) |
| Child | Gabriel Presnell (1745 - 1779) |
| Child | Margaret Presnell (1747 - ) |
| Child | Daniel Presnell (1748 - 1830) |
| Child | Elizabeth Presnell (1749 - ) |
| Child | Jonathan Presnell (1750 - 1840) |
| Child | Abraham Presnell (1750 - ) |
| Child | Elijah Presnell (1750 - ) |
| Child | John Presnell (1751 - ) |
| Child | Absolem Presnall (1753 - 1822) |
| Child | Stephen Presnell (1758 - ) |
| Child | Mary Mercy Presnell (1759 - 1796) |
| Child | William Presnell (1760 - ) |