| Father | Ephraim Osborn (1785 - 1866) |
| Mother | Lucy Saylor (1797 - 1880) |
| Sibling | Elizabeth Osborne (1819 - 1892) |
| Sibling | Jemima Osborne (1820 - ) |
| Sibling | James H. Osborne (1820 - 1881) |
| Sibling | Mahala Osborne (1821 - 1887) |
| Sibling | Naoma Osborne (1821 - ) |
| Sibling | Hiram Osborne (1822 - 1880) |
| Sibling | Ephraim Washington Osborne IV (1822 - 1865) |
| Sibling | Nancy Osborne (1825 - ) |
| Sibling | Haley Osborne (1827 - ) |
| Sibling | Martha Osborne (1827 - 1900) |
| Sibling | Mary Osborne (1829 - ) |
| Sibling | Lucy Osborne (1829 - 1904) |
| Sibling | Hattie Osborne (1831 - ) |
| Sibling | Nancy Osborne (1832 - ) |
| Sibling | Hester Osborne (1839 - 1933) |