| Father | Nathaniel Locke (1661 - 1734) |
| Mother | Dorothy Blake (1668 - 1737) |
| Sibling | John Locke (1689 - ) |
| Sibling | Dorothy Locke (1690 - ) |
| Sibling | Nathaniel Locke (1691 - ) |
| Sibling | Tryphena Locke (1692 - ) |
| Sibling | Elizabeth Locke (1694 - ) |
| Sibling | Rachel Locke (1695 - ) |
| Sibling | Joseph Locke (1697 - ) |
| Sibling | Nathaniel Locke (1699 - ) |
| Sibling | Timothy Locke (1700 - ) |
| Sibling | Samuel Locke (1701 - ) |
| Sibling | Alice Locke (1702 - ) |
| Sibling | Deborah Locke (1704 - 1735) |
| Sibling | Jonathan Locke (1705 - ) |
| Sibling | Mary Locke (1707 - ) |
| Sibling | Mehitable Locke (1708 - ) |