| Spouse | Rebecca Ussery (1785 - 1860) |
| Child | Druscilla Truesdale (1798 - 1865) |
| Child | Tharzy Truesdale (1799 - ) |
| Child | Son Truesdale (1801 - 1802) |
| Child | Mary Hollingsworth Truesdale (1802 - 1878) |
| Child | Sarah Nancy "Sallie" Truesdale (1803 - 1854) |
| Child | Millie Truesdale (1805 - 1874) |
| Child | John Henry Truesdale (1809 - 1858) |
| Child | Elizabeth Elvira Truesdale (1812 - 1881) |
| Child | Jane Rebecca Truesdale (1814 - 1886) |
| Child | James Rembert Truesdale Jr (1816 - 1870) |
| Child | George Hollingsworth Truesdale (1822 - 1857) |
| Child | Mahala Truesdale (1823 - 1859) |
| Child | Margaret Matilda Truesdale (1824 - 1864) |
| Child | Jesse T Truesdale (1830 - 1860) |