Individual Details

This might be William in 1840 in Breckinridge Co KY. If indeed both parents were dead, he may be the head of a household of a brother and several sisters.
William Huff: 1m 15-20, 1m 20-30, 2f 20-30, 2f 30-40

1850 Census. Mississippi Co, MO, Hh 199
Nancy Dowell, 38 and her children: Wayne, 15, James M. 13, William N., 12, Albert, 10 - all born in Kentucky, and Jacob Westley, 6, and Susan, 4, born Missouri
William Huff , 32, b. KY, with Benjamin 6 and E. A. Huff, female, age 3, born in Missouri.

1860 Census. Tywappity Twp, Charleston P.O., Mississippi Co, MO, Hh 67
William Hough, 47, b. KY
Elizabeth 19, b. KY - is this a new young wife, Alice & Sandy, her children?
Benjamin 17, b. MO
Alice, 4, b. MO
Elizabeth 12, b. MO
Sandy age 1 (male), b. MO
Four boarders

There is a marriage, Missouri Co, for William D. Huff, to Elizabeth Davis, 10 May 1857.

The following is a quite fanciful account of a probable son of William:
Goodspeed's History of Southeast Missouri, "Biographies of Mississippi County, 1888"
Benjamin Huff
Benjamin Huff, sheriff of Mississippi County, was born in that county on August 19, 1843, and is a son of William D. Huff, a native of Breckenridge County, Ky. The latter is a son of Benjamin Huff, who came from Germany to Breckenridge County, Ky., at a very early day, and was a settler with Daniel Boone, with whom he used to hunt.
He was the first sheriff of Breckenridge County, and was among the first to represent the county in the Legislature. He was in the Indian War, and was captured at one time on the Ohio River, at the mouth of Salt River by red men. They ut him on a raft and tied him with a buckskin thong, but he loosened it, pushed one of the guards off into the river, and shot the other.
He owned considerable land which he had taken up from the government.
The paternal grandmother was a sister of Ben. Hardin, who built
Hardinsburg Fort, a German settlement. William D. Huff was reared to farm life in his native State, in which he married Elizabeth Walls, also a native of Breckenridge County, Ky. In 1843 he went down the Ohio River on a flat-boat, which he had built for that purpose, to Bird's Point, Mississippi County, Mo. From thence he went to what is known as Mathews' Prairie. During the big flood in the spring of 1844, he removed to Fish Lake, and bought a pre-emption, with about ten or twelve acres improved, from a Mr. Bill George. Here he made a home and resided until his death in December 1860. His wife is also dead. They had four children, two of whom are living: Benjamin and Elizabeth, widow of Edwin Quinn. The subject of this sketch remained with his father until the latter's death. About this time, troops were called, and in Jun 1861 he enlisted in the Confederate army, joining Company
A, Fortieth Tennessee, provisional army. He participated in the battles of Corinth, Coffeeville and the siege of Island No. 10, of which he saw the surrender. He was taken prisoner by Gen. Grant and sent to Camp Douglas, Chicago, where he was kept six months, when he was exchanged and assigned to the Eighth Kentucky Regiment. Being captured again at Coffeeville in November 1862, he was taken to Oxford, Miss., where he was imprisoned two weeks, when he was paroled. Returning home he engaged in farming, which has since continued. He has been a resident of Charleston since December 8, 1884.
On January 1, 1863, he was united in marriage with Martha Hargan, a native of Hardin County, Ky., by whom he has one child, Martha B., who married James T. Brown, September 22, 1878. They have three children: Benjamin, Effie Maud and Thomas, all of whom live at Huff's Landing, Mississippi County. Mr. and Mrs. Huff are members of the Methodist Episcopal Church South. He is a member of the Masonic fraternity, and of the I.O.O.F. In 1884 he was elected sheriff and collector, and was re-elected sheriff in 1886. He is public-spirited, and is one of the prominent men of Mississippi County.