| Father | Sir William Sinclair 1st Earl of Caithness, 3rd Earl of Orkney, Baron of Roslin, builder of Rosslyn Chapel (1410 - 1484) |
| Mother | Marjory Sutherland (1436 - 1488) |
| Sibling | Eleanore Sinclair (1457 - 1518) |
| Sibling | Eleanor Sinclair ( - ) |
| Sibling | Lady Elizabeth Sinclair (1455 - 1498) |
| Sibling | Margaret Sinclair (1465 - ) |
| Sibling | Robert Sinclair (1447 - 1506) |
| Sibling | Alexander Sinclair (1454 - ) |
| Sibling | George Sinclair (1453 - ) |
| Sibling | Sir Oliver Sinclair of Roslin (1452 - 1520) |
| Sibling | Arthur Sinclair (1452 - ) |
| Sibling | William Sinclair 2nd Earl of Caithness (1445 - 1513) |
| Sibling | Oliver Sinclair (1458 - ) |
| Sibling | William Sinclair (1459 - 1513) |
| Sibling | Marjory Orkney Sinclair (1450 - 1480) |
| Sibling | Elizabeth Sinclair (1456 - 1498) |
| Sibling | Robert Sinclair ( - ) |
| Sibling | Margaret Sinclair (1465 - ) |
| Sibling | Catherine Sinclair (1476 - ) |
| Sibling | Henry Sinclair (1487 - ) |
| Sibling | Catherine Sinclair (1445 - 1486) |