| Spouse | Anna TIERNEY <23> (1833 - 1894) |
| Child | Julia Duty O'BRIEN (1854 - 1944) |
| Child | Mary Theresa (Mae) O'BRIEN <11> (1857 - 1919) |
| Child | Johanna " Jo" O'BRIEN (1862 - 1932) |
| Child | Patrick James " Jim" O'BRIEN (1863 - 1930) |
| Child | John "Jack" O'BRIEN (1865 - 1936) |
| Child | Michael "Mike" O'BRIEN (1866 - ) |
| Child | Denis O'BRIEN (1869 - ) |
| Child | Catherine "Kitty" O'BRIEN (1869 - 1964) |
| Child | Ellen Nell O'BRIEN (1871 - 1949) |
| Child | Margaret Madge O'BRIEN (1872 - 1939) |
| Child | Thomas O'BRIEN (1875 - ) |
| Child | Peter O'BRIEN (1877 - 1950) |
| Child | "Frank" Francis M. O'BRIEN (1879 - 1919) |
| Child | Nora O'BRIEN (1879 - 1961) |